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Current News From Trials

DR Management Trial
The Delivery Room Management Trial was perhaps our most ambitious effort ever. The DRM Trial evaluated three distinct approaches to stabilization and support of premature infants at high risk of respiratory distress syndrome. 36 participating centers successfully completed Phase 1. These centers participated in a series of web conferences that supported education regarding the use of nasal continuous positive airway pressure and the conduct of clinical trials. Phase II proceeded smoothly with few problems and few changes to the protol. Data collection was complete in June 2009. We enrolled 658 infants at 18 participating centers. The results of this study were presented at the Annual Meeting of Vermont Oxford Network in December 2009 and the Society for Pediatric Research in May 2010. The manuscript was published in the November 2011 issue of Pediatrics. Learn more...

Early Surfactant Replacement Trial
Enrollment in the Early Surfactant Replacement was completed with a total of 267 low birth weight infants enrolled. The results of this study were presented at the Society for Pediatric Research in May 2003 and the Annual Meeting of Vermont Oxford Network in December 2003. A manuscript is forthcoming.

Recent Publications & Presentations

Dunn MS, Kaempf J, de Klerk A, de Klerk R, Reilly M, Howard D, Ferrelli K, O'Conor J, Soll RF; for the Vermont Oxford Network DRM Study Group. Randomized Trial Comparing 3 Approaches to the Initial Respiratory Management of Preterm Neonates. Pediatrics. 2011 Nov;128(5):e1069-e1076. Epub 2011 Oct 24.

Edwards WH, Conner JM, Soll RF for the Vermont Oxford Network Neonatal Skin Care Study Group. The Effect of Prophylactic Ointment Therapy on Nosocomial Sepsis Rates and Skin Integrity in Infants with Birth Weights of 501 to 1000 g. Pediatrics 2004;113:1195-1203.

Delivery Room Management of Premature Infants at High Risk of Respiratory Distress Syndrome. Roger F. Soll, MD. Presented at Vermont Oxford Network Annual Meeting, December, 2002.

Early Surfactant Replacement Therapy in Premature Infants with Mild to Moderate Respiratory Distress Syndrome. Presented at Vermont Oxford Network Annual Meeting, December, 2002.

For more information, please contact:
Karla Ferrelli
802-865-4814 x212
karla@vtoxford.org 

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